Heterologous Desensitization of Opioid-stimulated Ca2+ Increase by Bradykinin or ATP in NG108-15 Cells
نویسندگان
چکیده
منابع مشابه
μ-Opioid receptor desensitization: homologous or heterologous?
There is considerable controversy over whether μ-opioid receptor (MOPr) desensitization is homologous or heterologous and over the mechanisms underlying such desensitization. In different cell types MOPr desensitization has been reported to involve receptor phosphorylation by various kinases, including G-protein-coupled receptor kinases (GRKs), second messenger and other kinases as well as pert...
متن کاملATP-activated nonselective cation current in NG108-15 cells.
ATP (1 mM) induced a biphasic increase in intracellular Ca2+ concentration ([Ca2+]i), i.e., an initial transient increase decayed to a level of sustained increase, in NG108-15 cells. The transient increase was inhibited by a phospholipase C inhibitor, 1-[6[[17beta-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H- pyrrole-2,5-dione (U73122), whereas the sustained increase was abolished by re...
متن کاملRegulation of an opioid-binding protein in NG108-15 cells parallels regulation of delta-opioid receptors.
An opioid-binding protein has recently been purified from bovine brain and cloned, and its cDNA sequence has been obtained. Indirect evidence suggests that this protein has a role in opioid-receptor function. However, because direct testing of its function by expression of its cDNA has not yet been possible and because its structure bears no resemblance to G protein-coupled receptors, the role ...
متن کاملEffects of Anions on ATP-Activated Nonselective Cation Current in NG108-15 Cells
Kaiho, Hiromi, Junko Kimura, Isao Matsuoka, and Hironori crease in the ATP-induced current when external Cl was Nakanishi. Effects of anions on ATP-activated nonselective cation replaced with methanesulfonic acid (MS) . In the present current in NG108-15 cells. J. Neurophysiol. 77: 2717–2722, 1997. study we investigated the effects of various external anions Extracellular ATP induces a nonselec...
متن کاملEvidence that muscarinic cholinergic receptors selectively interact with either the cyclic AMP or the inositol phosphate second-messenger response systems.
The relative capacities of muscarinic cholinergic receptor (MR) and bradykinin (BK)-receptor activation to increase phosphoinositide hydrolysis and to increase cytosolic Ca2+ were compared in NG108-15 neuroblastoma x glioma and 1321N1 human astrocytoma cells. In 1321N1 cells, the muscarinic cholinergic agonist carbachol and BK each stimulated a concentration-dependent accumulation of inositol p...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.28.16630